We will achieve orphan drug creation with an innovative business model.
Our group covers the whole spectrum of pharmaceutical activities from development to sales
OrphanPacific was founded by CMIC HOLDINGS, a leading and pioneer contract research organization (CRO) company in Japan, and MEDIPAL HOLDINGS, a leading pharmaceutical products wholesaler with more than 200 facilities across Japan, reaching out to all medical institutions and pharmacies nationwide.
Extensive collaboration with our parent companies which both have robust track records in the medical field allows OrphanPacific to cover the whole spectrum of pharmaceutical activities from development to promotion in Japan.
Continuous supply scheme with sale of both orphan drugs and Essential Drugs as two wheels
In order to secure a stable orphan drugs supply, OrphanPacific is also developing sales business of Essential Drugs that have been sold successfully. We are working towards the realization of our business success by organizing a scheme that combines orphan drugs and Essential Drugs as two wheels.
With a combination of Face-to-face and Online services, OrphanPacific promptly provides effective information to medical professionals.
With the Sales Representatives in offices nationwide plus the Online Medical Affairs service enables OrphanPacific to provide useful information to the healthcare professionals immediately.
Moreover, this collaboration enables timely collection of valuable information such as condition and treatment of each rare disease patients provides benefit and support not only to their treatment but also to other patients as well.
5 strengths of OrphanPacific
Products provided by OrphanPacific
|Classification of drugs
by efficacy or indication
|Number of patient||First
|150mg Tablet||Hypertension||-||March 1, 2018|
|Diazoxide（Diazoxide）||25mg Capsule||○||Hyperinsulinemic Hypoglycemia||（Persistent）
|April 1, 2017|
（Dantrolene Sodium Hydrate）
|○||Malignant Hyperthermia||4～5/Year4)||October 1, 2015|
|●||Neuroleptic Malignant Syndrome||100～300/Year3)|
Syndrome of Progressive Muscle Spasm
|10mg Tablet||Acute and Chronic Cough||－|
|Somazon®（Mecasermin）||10mg Injection||●||Insulin Receptor Abnormalities,
Growth Hormone Resistant Dwarfism
|283)||April 1, 2015|
|Normosang®（Hemin）||250mg Infusion||●||Acute Porphyria||362)||August 23, 2013|
|500mg Tablet||●||Urea Cycle Disorders||2861)||January 17, 2013|
1）Kato.et al., The status of nationwide registration of research projects for Specific Pediatric Chronic Diseases 2011.
2）Kawada et al., National epidemiological survey on hereditary porphyria (primary investigation) Result report
3）Edited by Orphan Drag Study Group, Handbook of Rare Diseases, Pharmaceutical Handbook 2009, pp. 39-40, Jiho, 2009
4）Mukaida et al., Journal of Japan Society of Clinical Anesthesia 32(5), 682-690, 2012
5）Kawakita et al., Journal of Japan Pediatric Society 115(3), 563-569, 2011
6）● indicates a disease designated as orphan drug, ○ indicates a disease with less than 50,000 patients